In 1994, at the age of 17, Nicodemou was cast as Katarina on Heartbreak High. Although the role was initially to be a 12-week stint, she remained on the show for three years. While filming the show, she completed her high school studies by correspondence. After leaving Heartbreak High, Nicodemou studied Tourism at TAFE.

She returned to television in 1998, playing Fiona Motson on the short-lived Breakers. In 1999, she played DuJour (the White Rabbit Girl) in The Matrix.